MM Kit is a combination of Mifepristone and Misoprostol used for medical abortion. It is prescribed under medical supervision and involves two visits for administration. MM Kit Price varies depending on location and healthcare provider, so it’s important to consult a licensed professional for accurate pricing information. Always follow medical advice for proper usage and post-treatment care.
Pharmacology of MM Kit Tablets
Mifepristone: Mifepristone is a synthetic steroid that exhibits anti-progestational activity by competing with progesterone at its receptor sites. It inhibits the action of both endogenous and exogenous progesterone, thereby disrupting the menstrual cycle and pregnancy. In the context of pregnancy, Mifepristone sensitizes the myometrium (uterine muscle) to prostaglandins, which induces uterine contractions. This action is essential for pregnancy termination.
Misoprostol: Misoprostol is a synthetic prostaglandin E1 analog that works by binding to prostaglandin receptors on myometrial cells, leading to increased calcium concentration, which stimulates uterine muscle contractions. It also softens the cervix, facilitating the expulsion of uterine contents. Misoprostol is used to complete the abortion process after Mifepristone administration.
Dosage & Administration
The MM Kit must only be prescribed by healthcare professionals capable of assessing gestational age, diagnosing ectopic pregnancies, and providing necessary surgical interventions in case of complications. The healthcare professional should be prepared to offer emergency care, including blood transfusions and resuscitation, if needed.
Day 1 (First Visit)
Mifepristone administration: The patient takes a single oral dose of Mifepristone (200 mg) under the supervision of a qualified healthcare provider in a clinic, medical office, or hospital.
Day 2 (Second Visit):
Misoprostol administration : 24-48 hours after Mifepristone, the patient takes four 200-microgram tablets (800 micrograms) of Misoprostol buccally or sublingually. The tablets should be placed on both sides of the cheek and gum or under the tongue. The patient waits for 30 minutes before swallowing any residue. During this time, the patient may experience cramps or gastrointestinal symptoms, for which medications may be prescribed. Clear instructions should be provided on what to do if excessive bleeding, significant discomfort, or other adverse reactions occur.
MM Kit খাওয়ার নিয়ম ও ব্যবহার বিধি
Day 10 to 14 (Third Visit):
Post-treatment examination: A follow-up visit is mandatory within 10-14 days to confirm the success of the abortion through clinical examination or ultrasound. If the pregnancy persists, the patient faces a risk of fetal malformations, and surgical intervention (MVA) is recommended.
Interactions of MM Kit Tablets
Mifepristone: While no specific drug or food interactions have been studied extensively, Mifepristone is metabolized by CYP 3A4, so drugs like Ketoconazole, Itraconazole, Erythromycin, and grapefruit juice may increase Mifepristone serum levels by inhibiting its metabolism.
Misoprostol: Misoprostol does not interfere with the therapeutic effects of aspirin in treating rheumatoid arthritis and does not significantly affect the absorption, blood levels, or platelet action of aspirin.
Contraindications
Mifepristone should not be administered to patients with any of the following conditions:
- Known allergy or hypersensitivity to Mifepristone, Misoprostol, or other prostaglandins.
- Suspected or confirmed ectopic pregnancy, as the treatment is ineffective in these cases.
- Presence of an intrauterine device (IUD) – it should be removed before starting treatment.
- Chronic adrenal insufficiency or hemorrhagic disorders.
- Concurrent use of anticoagulant medications.
- History of porphyria.
- Inadequate access to healthcare facilities equipped for emergency care, blood transfusions, or resuscitation.
Side Effects of MM Kit Tablets
- Mifepristone: Common side effects include vaginal bleeding, uterine cramping, nausea, vomiting, and diarrhea. Rarely, patients may experience pelvic pain, fainting, dizziness, or asthenia. Serious complications may include severe vaginal bleeding, shock, uterine rupture, and the need for surgical repair.
- Misoprostol: Side effects include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. The combination of Mifepristone and Misoprostol may result in uterine cramping and bleeding, which are expected.
Pregnancy and Lactation
- Pregnancy: Mifepristone is indicated only for the termination of pregnancies within 63 days of gestation. If pregnancy continues after treatment, the risk of fetal abnormalities increases, and surgical termination is recommended.
- Lactation: The excretion of Mifepristone in breast milk is unknown, and due to the potential effects on infants, breastfeeding mothers are advised to consult a doctor to determine whether they should discard their milk for a period after treatment.
- Misoprostol: It is unknown whether Misoprostol is excreted in human milk. However, due to the possibility of adverse effects like diarrhea in infants, Misoprostol should not be used in breastfeeding mothers.
Precautions & Warnings
- The combination of Mifepristone and Misoprostol should only be prescribed to the intended patient. It is not suitable for anyone else, especially if they might be pregnant or have an IUD in place.
- In case of failure to terminate pregnancy, surgical termination (MVA) should be considered.
- Patients with ongoing pregnancies after treatment may face risks of fetal malformations, and surgical intervention may be required.
MM Kit Price Tablet 200 mg+200 mcg
5 Tablets (1 Box)
৳ 270.00
